Effect of epidural stimulation of the lubosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
Susan Harkema, Ph.D, Yuri Gerasimenko, Ph.D., Jonathan Hodes, M.D., Joel Burdick, Ph.D., Claudia Angeli, Ph.D, Yangsheng Chen, Ph.D, Christie Ferreira, Andrea Willhite, Enrico Rejc, Ph.D., Robert G. Grossman, M.D., Reggie Edgerton, Ph.D.
Fig 1 is Radiographic and clinical characteristics of subject with motor complete, but sensory incomplete SCI.
Note that the implant is not at the injury site.
Before implant is placed in the subject, the subject goes thru Locomotor Training including:
- Stand and step training
- Body weight support
There are Three time points over two year period; during the pre-training subject has had:
- Zero sessions for the first period;
- 66 sessions in the second period; and finally
- 170 sessions in the last period.
EMG activity with sc-ES during independent standing
The output of the spinal circuitry can be sufficiently modulated by the proprioceptive input to sustain independent standing
EMG activity increases in amplitude and becomes more constant bilaterally in most muscles with independent standing occurring at 8 V.
Reducing BWS changed the EMG amplitudes and oscillatory patterns differently among muscles .
(15Hz) (4/10/15- : 3/9+)
1 – 8V and 65% BWS
8V BWS from 45% to 5%.