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Testosterone Replacement Therapy in Combination with Electrical Stimulation and Standing: Effect on Muscle and Bone in Spinal Cord Injured Males

The aim of this study is to understand what happens to muscle and bone in spinal cord injured males after 20 weeks (5 months) of training using stand training with or without testosterone replacement therapy (TRT) in the form of a gel containing testosterone and electrical stimulation (ES).


The research participants will be randomly assigned to one of the four training groups based upon age, time since injury, and level of injury. Participants will not know if they are receiving the testosterone or the placebo gel. The placebo gel contains no testosterone.

    1. Stand training with a placebo gel
    2. Stand training and electrical stimulation (ES) with a placebo gel
    3. Stand training with TRT gel
    4. Stand training and ES with TRT gel

Assessments to evaluate TRT safety, training effects, and/or optimize training parameters are conducted before, periodically throughout the training, after the 20 weeks of training, and at a 3-month follow-up.

Learn more details about this study.

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